Article
Mutations or copy number losses of CD58 and TP53 genes in diffuse large B cell lymphoma are independent unfavorable prognostic factors.
Oncotarget - 13 Dec 2016
Cao Yang, Zhu Tao, Zhang Peiling, Xiao Min, Yi Shuhua, Yang Yan, Li Qinlu, Ling Shaoping, Wang Yafei, Gao Lili, Zhu Li, Wang Jue, Wang Na, Huang Liang, Zhang Peihong, Zhai Qiongli, Qiu Lugui, Zhou Jianfeng
Abstract excerpt
The advent of next generation sequencing (NGS) technologies has expedited the discovery of novel genetic lesions in DLBCL. The prognostic significance of these identified gene mutations is largely unknown. In this study, we performed NGS for the 27 genes most frequently implicated in 196 patients. Interestingly, TP53 mutations were found to be significantly more common in DLBCL with MYC translocations (r = 0.446,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.