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Article

Significance of IDH mutations varies with tumor histology, grade, and genetics in Japanese glioma patients.

Cancer science - 1 Mar 2012

Mukasa Akitake, Takayanagi Shunsaku, Saito Kuniaki, Shibahara Junji, Tabei Yusuke, Furuya Kazuhide, Ide Takafumi, Narita Yoshitaka, Nishikawa Ryo, Ueki Keisuke, Saito Nobuhito

Abstract excerpt

Mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2 are found frequently in malignant gliomas and are likely involved in early gliomagenesis. To understand the prevalence of these mutations and their relationship to other genetic alterations and impact on prognosis for Japanese glioma patients, we analyzed 250 glioma cases. Mutations of IDH1 and IDH2 were found in 73 (29%) and 2 (1%) cases, respectively. All...

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Source

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Identifiers

PMID: 22136423
DOI: 10.1111/j.1349-7006.2011.02175.x
PMCID: PMC7713609

Genes

IDH1
IDH2
MGMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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