Article
The Ty1 Retrotransposon Restriction Factor p22 Targets Gag.
PLoS genetics - 1 Oct 2015
Tucker Jessica M, Larango Morgan E, Wachsmuth Lucas P, Kannan Natarajan, Garfinkel David J
Abstract excerpt
A novel form of copy number control (CNC) helps maintain a low number of Ty1 retrovirus-like transposons in the Saccharomyces genome. Ty1 produces an alternative transcript that encodes p22, a trans-dominant negative inhibitor of Ty1 retrotransposition whose sequence is identical to the C-terminal half of Gag. The level of p22 increases with copy number and inhibits normal Ty1 virus-like particle (VLP) assembly...
Topics
- Alleles
- Gene Dosage
- Gene Products, gag
- Genome, Fungal
- Retroelements
- Saccharomyces cerevisiae