Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Ty1 Retrotransposon Restriction Factor p22 Targets Gag.

PLoS genetics - 1 Oct 2015

Tucker Jessica M, Larango Morgan E, Wachsmuth Lucas P, Kannan Natarajan, Garfinkel David J

Abstract excerpt

A novel form of copy number control (CNC) helps maintain a low number of Ty1 retrovirus-like transposons in the Saccharomyces genome. Ty1 produces an alternative transcript that encodes p22, a trans-dominant negative inhibitor of Ty1 retrotransposition whose sequence is identical to the C-terminal half of Gag. The level of p22 increases with copy number and inhibits normal Ty1 virus-like particle (VLP) assembly...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Gene Dosage
Share to Gene Products, gag

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genome, Fungal

Share to Retroelements

Share to Saccharomyces cerevisiae

Source

Open in PubMed Open full text

Identifiers

PMID: 26451601
DOI: 10.1371/journal.pgen.1005571
PMCID: PMC4599808

Genes

UBN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Ty1 Retrotransposon Restriction Factor p22 Targets Gag.PMID 26451601Read ↗

Structure of a Ty1 restriction factor reveals the molecular basis of transposition copy number control.Semantic proximity Read ↗

Evolution of Ty1 copy number control in yeast by horizontal transfer of a <i>gag</i> geneSemantic proximity Read ↗

BUD22 affects Ty1 retrotransposition and ribosome biogenesis in Saccharomyces cerevisiae.Semantic proximity Read ↗

Novel transcript truncating function of Rap1p revealed by synthetic codon-optimized Ty1 retrotransposon.Semantic proximity Read ↗

Ty5 gag mutations increase retrotransposition and suggest a role for hydrogen bonding in the function of the nucleocapsid zinc finger.Semantic proximity Read ↗

A genetic and structural study of genome rearrangements mediated by high copy repeat Ty1 elements.Semantic proximity Read ↗

A nucleosomal surface defines an integration hotspot for the Saccharomyces cerevisiae Ty1 retrotransposon.Semantic proximity Read ↗

Control of yeast retrotransposons mediated through nucleoporin evolution.Semantic proximity Read ↗

Multiple regulators of Ty1 transposition in Saccharomyces cerevisiae have conserved roles in genome maintenance.Semantic proximity Read ↗

The RNAPII-CTD Maintains Genome Integrity through Inhibition of Retrotransposon Gene Expression and Transposition.Semantic proximity Read ↗

Functional analysis of N-terminal residues of ty1 integrase.Semantic proximity Read ↗

P-body components are required for Ty1 retrotransposition during assembly of retrotransposition-competent virus-like particles.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.