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Article

Differential regulation of protein tyrosine kinase signalling by Dock and the PTP61F variants.

The FEBS journal - 1 Jul 2017

Willoughby Lee F, Manent Jan, Allan Kirsten, Lee Han, Portela Marta, Wiede Florian, Warr Coral, Meng Tzu-Ching, Tiganis Tony, Richardson Helena E

Abstract excerpt

Tyrosine phosphorylation-dependent signalling is coordinated by the opposing actions of protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs). There is a growing list of adaptor proteins that interact with PTPs and facilitate the dephosphorylation of substrates. The extent to which any given adaptor confers selectivity for any given substrate in vivo remains unclear. Here we have taken...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28544778
DOI: 10.1111/febs.14118

Genes

PVR
EGFR

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