Association between Prostinogen (KLK15) genetic variants and prostate cancer risk and aggressiveness in Australia and a meta-analysis of GWAS data.

doi:10.1371/journal.pone.0026527

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Article

Association between Prostinogen (KLK15) genetic variants and prostate cancer risk and aggressiveness in Australia and a meta-analysis of GWAS data.

PloS one - 1 Jan 2011

Batra Jyotsna, Lose Felicity, O'Mara Tracy, Marquart Louise, Stephens Carson, Alexander Kimberly, Srinivasan Srilakshmi, Eeles Rosalind A, Easton Douglas F, Al Olama Ali Amin, Kote-Jarai Zsofia, Guy Michelle, Muir Kenneth, Lophatananon Artitaya, Rahman Aneela A, Neal David E, Hamdy Freddie C, Donovan Jenny L, Chambers Suzanne, Gardiner Robert A, Aitken Joanne, Yaxley John, Kedda Mary-Anne, Clements Judith A, Spurdle Amanda B

Abstract excerpt

BACKGROUND: Kallikrein 15 (KLK15)/Prostinogen is a plausible candidate for prostate cancer susceptibility. Elevated KLK15 expression has been reported in prostate cancer and it has been described as an unfavorable prognostic marker for the disease. OBJECTIVES: We performed a comprehensive analysis of association of variants in the KLK15 gene with prostate cancer risk and aggressiveness by genotyping tagSNPs, as...

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PMID: 22132073
DOI: 10.1371/journal.pone.0026527
PMCID: PMC3223160

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KLK15

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