Article
Associations of prostate cancer risk variants with disease aggressiveness: results of the NCI-SPORE Genetics Working Group analysis of 18,343 cases.
Human genetics - 1 Apr 2015
Helfand Brian T, Roehl Kimberly A, Cooper Phillip R, McGuire Barry B, Fitzgerald Liesel M, Cancel-Tassin Geraldine, Cornu Jean-Nicolas, Bauer Scott, Van Blarigan Erin L, Chen Xin, Duggan David, Ostrander Elaine A, Gwo-Shu Mary, Zhang Zuo-Feng, Chang Shen-Chih, Jeong Somee, Fontham Elizabeth T H, Smith Gary, Mohler James L, Berndt Sonja I, McDonnell Shannon K, Kittles Rick, Rybicki Benjamin A, Freedman Matthew, Kantoff Philip W, Pomerantz Mark, Breyer Joan P, Smith Jeffrey R, Rebbeck Timothy R, Mercola Dan, Isaacs William B, Wiklund Fredrick, Cussenot Olivier, Thibodeau Stephen N, Schaid Daniel J, Cannon-Albright Lisa, Cooney Kathleen A, Chanock Stephen J, Stanford Janet L, Chan June M, Witte John, Xu Jianfeng, Bensen Jeannette T, Taylor Jack A, Catalona William J
Abstract excerpt
Genetic studies have identified single nucleotide polymorphisms (SNPs) associated with the risk of prostate cancer (PC). It remains unclear whether such genetic variants are associated with disease aggressiveness. The NCI-SPORE Genetics Working Group retrospectively collected clinicopathologic information and genotype data for 36 SNPs which at the time had been validated to be associated with PC risk from 25,674...
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