Germline Mutations in the Kallikrein 6 Region and Predisposition for Aggressive Prostate Cancer.

doi:10.1093/jnci/djw258

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Article

Germline Mutations in the Kallikrein 6 Region and Predisposition for Aggressive Prostate Cancer.

Journal of the National Cancer Institute - 1 Apr 2017

Briollais Laurent, Ozcelik Hilmi, Xu Jingxiong, Kwiatkowski Maciej, Lalonde Emilie, Sendorek Dorota H, Fleshner Neil E, Recker Franz, Kuk Cynthia, Olkhov-Mitsel Ekaterina, Savas Sevtap, Hanna Sally, Juvet Tristan, Hunter Geoffrey A, Friedlander Matt, Li Hong, Chadwick Karen, Prassas Ioannis, Soosaipillai Antoninus, Randazzo Marco, Trachtenberg John, Toi Ants, Shiah Yu-Jia, Fraser Michael, van der Kwast Theodorus, Bristow Robert G, Bapat Bharati, Diamandis Eleftherios P, Boutros Paul C, Zlotta Alexandre R

Abstract excerpt

Background: There is a need for markers that can specifically identify individuals at increased risk of harboring aggressive forms of prostate cancer (PCa). Methods: We surveyed the Kallikrein ( KLK ) region ( KLK 1-15) for single-nucleotide polymorphisms (SNPs) associated with aggressive PCa (Gleason Score ≥ 8) in 1858 PCa patients. Discovery cohorts (Swiss arm of the European Randomized Study of Screening for...

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PMID: 28376164
DOI: 10.1093/jnci/djw258

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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