Article
New variants at 10q26 and 15q21 are associated with aggressive prostate cancer in a genome-wide association study from a prostate biopsy screening cohort.
Cancer biology & therapy - 1 Dec 2011
Nam Robert K, Zhang William, Siminovitch Katherine, Shlien Adam, Kattan Michael W, Klotz Laurence H, Trachtenberg John, Lu Yan, Zhang Jinyi, Yu Changhong, Toi Ants, Loblaw D Andrew, Venkateswaran Vasundara, Stanimirovic Aleksandra, Sugar Linda, Malkin David, Seth Arun, Narod Steven A
Abstract excerpt
PURPOSE: To identify and examine polymorphisms of genes associated with aggressive and clinical significant forms of prostate cancer among a screening cohort. EXPERIMENTAL DESIGN: We conducted a genome-wide association study among patients with aggressive forms of prostate cancer and biopsy-proven normal controls ascertained from a prostate cancer screening program. We then examined significant associations of...
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