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Article

A cell-penetrating peptide based on the interaction between c-Src and connexin43 reverses glioma stem cell phenotype.

Cell death & disease - 23 Jan 2014

Gangoso E, Thirant C, Chneiweiss H, Medina J M, Tabernero A

Abstract excerpt

Connexin43 (Cx43), the main gap junction channel-forming protein in astrocytes, is downregulated in malignant gliomas. These tumors are composed of a heterogeneous population of cells that include many with stem-cell-like properties, called glioma stem cells (GSCs), which are highly tumorigenic a...

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Identifiers

PMID: 24457967
DOI: 10.1038/cddis.2013.560
PMCID: PMC4040690

Genes

GSC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24457967-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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A cell-penetrating peptide based on the interaction between c-Src and connexin43 reverses glioma stem cell phenotype.PMID 24457967Read ↗

Connexin 43 reverses malignant phenotypes of glioma stem cells by modulating E-cadherin.Semantic proximity Read ↗

Connexin43 inhibits the oncogenic activity of c-Src in C6 glioma cells.Semantic proximity Read ↗

Connexin 43 drives glioblastoma cancer stem cell phenotypes through a WNK lysine-deficient protein kinase 1-c-MYC signaling axisSemantic proximity Read ↗

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Reversion of the neoplastic phenotype of human glioblastoma cells by connexin 43 (cx43).Semantic proximity Read ↗

Mapping glioblastoma spreading: connexin43 and glial dynamic in mouse and human glioblastoma microenvironmentSemantic proximity Read ↗

Targeting metabolic plasticity in glioma stem cells in vitro and in vivo through specific inhibition of c-Src by TAT-Cx43266-283Semantic proximity Read ↗

Connexin43 confers Temozolomide resistance in human glioma cells by modulating the mitochondrial apoptosis pathway.Semantic proximity Read ↗

Human cytomegalovirus immediate early proteins promote degradation of connexin 43 and disrupt gap junction communication: implications for a role in gliomagenesisSemantic proximity Read ↗

Cx43 Enhances Response to BRAF/MEK Inhibitors by Reducing DNA Repair CapacitySemantic proximity Read ↗

Human Neural Stem Cells Target Experimental Intracranial Medulloblastoma and Deliver a Therapeutic Gene Leading to Tumor RegressionSemantic proximity Read ↗

Connexin43 pseudogene is expressed in tumor cells and inhibits growth.Semantic proximity Read ↗

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