Article
A cell-penetrating peptide based on the interaction between c-Src and connexin43 reverses glioma stem cell phenotype.
Cell death & disease - 23 Jan 2014
Gangoso E, Thirant C, Chneiweiss H, Medina J M, Tabernero A
Abstract excerpt
Connexin43 (Cx43), the main gap junction channel-forming protein in astrocytes, is downregulated in malignant gliomas. These tumors are composed of a heterogeneous population of cells that include many with stem-cell-like properties, called glioma stem cells (GSCs), which are highly tumorigenic and lack Cx43 expression. Interestingly, restoring Cx43 reverses GSC phenotype and consequently reduces their...
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