Article
Connexin43 confers Temozolomide resistance in human glioma cells by modulating the mitochondrial apoptosis pathway.
Neuropharmacology - 1 Dec 2013
Gielen Paul R, Aftab Qurratulain, Ma Noreen, Chen Vincent C, Hong Xiaoting, Lozinsky Shannon, Naus Christian C, Sin Wun Chey
Abstract excerpt
Glioblastoma multiforme (GBM) is the most aggressive astrocytoma, and therapeutic options are generally limited to surgical resection, radiotherapy, and Temozolomide (TMZ) chemotherapy. TMZ is a DNA alkylating agent that causes DNA damage and induces cell death. Unfortunately, glioma cells often develop resistance to TMZ treatment, with DNA de-methylation of the MGMT promoter identified as the primary reason....
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