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Article

Chimeric Theiler's virus with altered tropism for the central nervous system.

Journal of virology - 1 May 1994

Jarousse N, Fiette L, Grant R A, Hogle J M, McAllister A, Michiels T, Aubert C, Tangy F, Brahic M, Peña Rossi C

Abstract excerpt

Theiler's virus is a neurotropic murine picornavirus which, depending on the strain, causes either an acute encephalitis or a persistent demyelinating disease. Following intracranial inoculation, the demyelinating strains infect sequentially the grey matter of the brain, the grey matter of the spinal cord, and finally the white matter of the spinal cord, where they persist and cause chronic demyelination. The...

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Identifiers

PMID: 8151749
DOI: 10.1128/JVI.68.5.2781-2786.1994
PMCID: PMC236765

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