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Article

Virus persistence in an animal model of multiple sclerosis requires virion attachment to sialic acid coreceptors.

Journal of virology - 1 Aug 2004

Kumar A S Manoj, Reddi Honey V, Kung Aisha Y, Dal Canto Mauro, Lipton Howard L

Abstract excerpt

Persistent Theiler's virus infection in the central nervous system (CNS) of mice provides a highly relevant animal model for multiple sclerosis. The low-neurovirulence DA strain uses sialic acid as a coreceptor for cell binding before establishing infection. During adaptation of DA virus to growth in sialic acid-deficient cells, three amino acid substitutions (G1100D, T1081I, and T3182A) in the capsid arose, and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15280494
DOI: 10.1128/JVI.78.16.8860-8867.2004
PMCID: PMC479047

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Virus persistence in an animal model of multiple sclerosis requires virion attachment to sialic acid coreceptors.PMID 15280494Read ↗

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