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Article

Virus persistence in an animal model of multiple sclerosis requires virion attachment to sialic acid coreceptors.

Journal of virology - 1 Aug 2004

Kumar A S Manoj, Reddi Honey V, Kung Aisha Y, Dal Canto Mauro, Lipton Howard L

Abstract excerpt

Persistent Theiler's virus infection in the central nervous system (CNS) of mice provides a highly relevant animal model for multiple sclerosis. The low-neurovirulence DA strain uses sialic acid as a coreceptor for cell binding before establishing infection. During adaptation of DA virus to growt...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15280494
DOI: 10.1128/JVI.78.16.8860-8867.2004
PMCID: PMC479047

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15280494-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Virus persistence in an animal model of multiple sclerosis requires virion attachment to sialic acid coreceptors.PMID 15280494Read ↗

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Sialylation of the Host Receptor May Modulate Entry of Demyelinating Persistent Theiler's VirusSemantic proximity Read ↗

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The role of myelin in Theiler's virus persistence in the central nervous system.Semantic proximity Read ↗

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