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Article

TGF beta1 polymorphisms are candidate predictors of the clinical response to rituximab in rheumatoid arthritis.

Joint bone spine - 1 Oct 2012

Daïen Claire Immediato, Fabre Sylvie, Rittore Cécile, Soler Stephan, Daïen Vincent, Tejedor Gautier, Cadart Doris, Molinari Nicolas, Daurès Jean-Pierre, Jorgensen Christian, Touitou Isabelle

Abstract excerpt

OBJECTIVE: To evaluate the association between several candidate single-nucleotide polymorphisms (SNPs) and responsiveness to rituximab in patients with rheumatoid arthritis (RA). METHODS: Sixty-three RA patients were included. Nine genes (13 SNPs) were subsequently analyzed, including those coding for cytokines involved in synovitis (IL10, LTA, TGFβ1, TNF-α, TNF receptor II) and genes associated with RA...

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Topics

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Share to Antibodies, Monoclonal, Murine-Derived
Share to Antirheumatic Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Arthritis, Rheumatoid

Share to Rituximab

Share to STAT4 Transcription Factor

Share to TNF Receptor-Associated Factor 1

Share to Transforming Growth Factor beta1

Share to Tumor Necrosis Factor alpha-Induced Protein 3

Source

Identifiers

PMID: 22129793
DOI: 10.1016/j.jbspin.2011.10.007

Genes

TNF
LTA
PTPN22
STAT4
TNFAIP3
TRAF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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