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Article

Genetic Biomarkers as Predictors of Response to Tocilizumab in Rheumatoid Arthritis: A Systematic Review and Meta-Analysis.

Genes - 20 Jul 2022

Janahiraman Sivakami, Too Chun Lai, Lee Kai Wei, Shahril Nor Shuhaila, Leong Chee Onn

Abstract excerpt

Rheumatoid arthritis (RA) is a lifelong, debilitating disease which incredibly impacts a patient's quality of life if not treated to the optimal target. The clinical response of tocilizumab, an interleukin-6 (IL-6) inhibitor, is associated with several gene polymorphisms, particularly targeting the IL-6 pathway. This systematic review and meta-analysis seeks to investigate genetic biomarkers that predict the...

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Share to Antibodies, Monoclonal, Humanized
Share to Antirheumatic Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Arthritis, Rheumatoid

Share to Genetic Markers

Share to Interleukin-6

Share to Polymorphism, Single Nucleotide

Share to Quality of Life

Source

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Identifiers

PMID: 35886067
DOI: 10.3390/genes13071284
PMCID: PMC9323282

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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