Article
Validation study of genetic biomarkers of response to TNF inhibitors in rheumatoid arthritis.
PloS one - 1 Jan 2018
Lopez-Rodriguez Rosario, Perez-Pampin Eva, Marquez Ana, Blanco Francisco J, Joven Beatriz, Carreira Patricia, Ferrer Miguel Angel, Caliz Rafael, Valor Lara, Narvaez Javier, Cañete Juan D, Ordoñez Maria Del Carmen, Manrique-Arija Sara, Vasilopoulos Yiannis, Balsa Alejandro, Pascual-Salcedo Dora, Moreno-Ramos Manuel J, Alegre-Sancho Juan Jose, Navarro-Sarabia Federico, Moreira Virginia, Garcia-Portales Rosa, Raya Enrique, Magro-Checa Cesar, Martin Javier, Gomez-Reino Juan J, Gonzalez Antonio
Abstract excerpt
Genetic biomarkers are sought to personalize treatment of patients with rheumatoid arthritis (RA), given their variable response to TNF inhibitors (TNFi). However, no genetic biomaker is yet sufficiently validated. Here, we report a validation study of 18 previously reported genetic biomarkers, including 11 from GWAS of response to TNFi. The validation was attempted in 581 patients with RA that had not been...
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