Replication of PTPRC as genetic biomarker of response to TNF inhibitors in patients with rheumatoid arthritis.

doi:10.1038/tpj.2015.29

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Article

Replication of PTPRC as genetic biomarker of response to TNF inhibitors in patients with rheumatoid arthritis.

The pharmacogenomics journal - 1 Apr 2016

Ferreiro-Iglesias A, Montes A, Perez-Pampin E, Cañete J D, Raya E, Magro-Checa C, Vasilopoulos Y, Sarafidou T, Caliz R, Ferrer M A, Joven B, Carreira P, Balsa A, Pascual-Salcedo D, Blanco F J, Moreno-Ramos M J, Fernández-Nebro A, Ordóñez M C, Alegre-Sancho J J, Narváez J, Navarro-Sarabia F, Moreira V, Valor L, García-Portales R, Marquez A, Martin J, Gómez-Reino J J, Gonzalez A

Abstract excerpt

Genetic biomarkers could be useful for orienting treatment of patients with rheumatoid arthritis (RA), but none has been convincingly validated yet. Putative biomarkers include 14 single nucleotide polymorphisms that have shown association with response to TNF inhibitors (TNFi) in candidate gene studies and that we assayed here in 755 RA patients. Three of them, in the PTPRC, IL10 and CHUK genes, were...

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Identifiers

PMID: 25896535
DOI: 10.1038/tpj.2015.29

Genes

PTPRC
CHUK
TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Replication of PTPRC as genetic biomarker of response to TNF inhibitors in patients with rheumatoid arthritis.PMID 25896535Read ↗

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