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Article

Replication of PTPRC as genetic biomarker of response to TNF inhibitors in patients with rheumatoid arthritis.

The pharmacogenomics journal - 1 Apr 2016

Ferreiro-Iglesias A, Montes A, Perez-Pampin E, Cañete J D, Raya E, Magro-Checa C, Vasilopoulos Y, Sarafidou T, Caliz R, Ferrer M A, Joven B, Carreira P, Balsa A, Pascual-Salcedo D, Blanco F J, Moreno-Ramos M J, Fernández-Nebro A, Ordóñez M C, Alegre-Sancho J J, Narváez J, Navarro-Sarabia F, Moreira V, Valor L, García-Portales R, Marquez A, Martin J, Gómez-Reino J J, Gonzalez A

Abstract excerpt

Genetic biomarkers could be useful for orienting treatment of patients with rheumatoid arthritis (RA), but none has been convincingly validated yet. Putative biomarkers include 14 single nucleotide polymorphisms that have shown association with response to TNF inhibitors (TNFi) in candidate gene...

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Source

Identifiers

PMID: 25896535
DOI: 10.1038/tpj.2015.29

Genes

PTPRC
CHUK
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25896535-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Replication of PTPRC as genetic biomarker of response to TNF inhibitors in patients with rheumatoid arthritis.PMID 25896535Read ↗

Replication of association of the PTPRC gene with response to anti-tumor necrosis factor therapy in a large UK cohort.Semantic proximity Read ↗

Polymorphisms in STAT4 and PTPRC genes in rheumatoid arthritis: a Brazilian study and meta-analysis of susceptibility and TNFi response.Semantic proximity Read ↗

Rheumatoid arthritis risk allele PTPRC is also associated with response to anti-tumor necrosis factor alpha therapy.Semantic proximity Read ↗

Systematic review and meta-analysis: pharmacogenetics of anti-TNF treatment response in rheumatoid arthritis.Semantic proximity Read ↗

Polymorphisms in STAT4, PTPN2, PSORS1C1 and TRAF3IP2 Genes Are Associated with the Response to TNF Inhibitors in Patients with Rheumatoid Arthritis.Semantic proximity Read ↗

Validation study of genetic biomarkers of response to TNF inhibitors in rheumatoid arthritis.Semantic proximity Read ↗

Confirmation of an IRAK3 polymorphism as a genetic marker predicting response to anti-TNF treatment in rheumatoid arthritis.Semantic proximity Read ↗

PTPN22 1858 C/T polymorphism is associated with alteration of cytokine profiles as a potential pathogenic mechanism in rheumatoid arthritis.Semantic proximity Read ↗

Validation of GWAS-Identified Variants for Anti-TNF Drug Response in Rheumatoid Arthritis: A Meta-Analysis of Two Large Cohorts.Semantic proximity Read ↗

TRAF1/C5 but not PTPRC variants are potential predictors of rheumatoid arthritis response to anti-tumor necrosis factor therapy.Semantic proximity Read ↗

Integration of Known DNA, RNA and Protein Biomarkers Provides Prediction of Anti-TNF Response in Rheumatoid Arthritis: Results from the COMBINE StudySemantic proximity Read ↗

Association of RETN and TNFRSF1B polymorphisms with TNF-α inhibitor response in rheumatoid arthritis patientsSemantic proximity Read ↗

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