Article
Comparing ERCC1 protein expression, mRNA levels, and genotype in squamous cell carcinomas of the head and neck treated with concurrent chemoradiation stratified by HPV status.
Head & neck - 1 Jun 2012
Hao Desirée, Lau Harold Y, Eliasziw Misha, Box Alan, Diaz Román, Klimowicz Alexander C, Shin Brian, Lees-Miller Susan P, Magliocco Anthony M
Abstract excerpt
BACKGROUND: Previous studies examining excision repair cross-complementation group 1 (ERCC1) in squamous cell carcinoma of the head and neck (SCCHN) have not compared methods of ERCC1 testing nor been stratified by human papillomavirus (HPV) status. METHODS: ERCC1 protein expression, mRNA, and genotype were retrospectively evaluated from pretreatment biopsies in 55 patients with SCCHN treated with chemoradiation....
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