Article
DNA-repair gene polymorphisms predict favorable clinical outcome among patients with advanced squamous cell carcinoma of the head and neck treated with cisplatin-based induction chemotherapy.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 Sept 2006
Quintela-Fandino Miguel, Hitt Ricardo, Medina Pedro P, Gamarra Soledad, Manso Luis, Cortes-Funes Hernan, Sanchez-Cespedes Montserrat
Abstract excerpt
PURPOSE: Cisplatin kills tumor cells through DNA cross linking. Alterations in the function of DNA repair genes may affect DNA repair proficiency and influence cancer patients' response to cisplatin. We studied whether single nucleotide polymorphisms (SNPs) of DNA repair genes predict the respons...
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