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Article

Conditional analysis identifies three novel major histocompatibility complex loci associated with psoriasis.

Human molecular genetics - 1 Dec 2012

Knight Jo, Spain Sarah L, Capon Francesca, Hayday Adrian, Nestle Frank O, Clop Alex, Barker Jonathan N, Weale Michael E, Trembath Richard C

Abstract excerpt

Psoriasis is a common, chronic, inflammatory skin disorder. A number of genetic loci have been shown to confer risk for psoriasis. Collectively, these offer an integrated model for the inherited basis for susceptibility to psoriasis that combines altered skin barrier function together with the dysregulation of innate immune pathogen sensing and adap-tive immunity. The major histocompatibility complex (MHC)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22914738
DOI: 10.1093/hmg/dds344
PMCID: PMC3490509

Genes

MICA
MICB

Provenance

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