Article
Pseudouridine at position 55 in tRNA controls the contents of other modified nucleotides for low-temperature adaptation in the extreme-thermophilic eubacterium Thermus thermophilus.
Nucleic acids research - 1 Mar 2011
Ishida Kazuo, Kunibayashi Takashi, Tomikawa Chie, Ochi Anna, Kanai Tamotsu, Hirata Akira, Iwashita Chikako, Hori Hiroyuki
Abstract excerpt
Pseudouridine at position 55 (Ψ55) in eubacterial tRNA is produced by TruB. To clarify the role of the Ψ55 modification, we constructed a truB gene disruptant (ΔtruB) strain of Thermus thermophilus which is an extreme-thermophilic eubacterium. Unexpectedly, the ΔtruB strain exhibited severe growth retardation at 50 °C. We assumed that these phenomena might be caused by lack of RNA chaperone activity of TruB,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.