Article
Mice over-expressing salmon calcitonin have strongly attenuated osteoarthritic histopathological changes after destabilization of the medial meniscus.
Osteoarthritis and cartilage - 1 Feb 2012
Sondergaard B C, Catala-Lehnen P, Huebner A K, Bay-Jensen A-C, Schinke T, Henriksen K, Schilling S, Haberland M, Nielsen R H, Amling M, Karsdal M A
Abstract excerpt
OBJECTIVE: Calcitonin is well-known for its inhibitory actions on bone-resorbing osteoclasts and recently potential beneficial effects on cartilage were shown. We investigated effects of salmon calcitonin (sCT) on the articular cartilage and bone, after destabilization of the medial meniscus (DMM) in normal and sCT over-expressing mice. DESIGN: Bone phenotype of transgenic (TG) C57Bl/6 mice over-expressing sCT at...
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