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Article

Calcitonin Deficiency in Mice Progressively Results in High Bone Turnover

29 Sept 2006

Abstract excerpt

UNLABELLED: Although the pharmacological action of calcitonin (CT) as an inhibitor of bone resorption is well established, there is still some controversy regarding its physiological function. Unexpectedly, Calca-deficient mice lacking CT and alpha-calcitonin gene-related peptide (alphaCGRP) were described to have a high bone mass phenotype caused by increased bone formation with normal bone resorption. Here we...

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PMID: 17002587
DOI: 10.1359/jbmr.060820

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