Article
Inactivation of the gene encoding procalcitonin prevents antibody-mediated arthritis.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] - 1 May 2023
Maleitzke Tazio, Dietrich Tamara, Hildebrandt Alexander, Weber Jérôme, Appelt Jessika, Jahn Denise, Otto Ellen, Zocholl Dario, Jiang Shan, Baranowsky Anke, Duda Georg N, Tsitsilonis Serafeim, Keller Johannes
Abstract excerpt
BACKGROUND: Procalcitonin (PCT) is applied as a sensitive biomarker to exclude bacterial infections in patients with rheumatoid arthritis (RA) flare-ups. Beyond its diagnostic value, little is known about the pathophysiological role of PCT in RA. METHODS: Collagen antibody-induced arthritis (CAIA) was induced in Calca-deficient mice (Calca-/-), lacking PCT (n = 15), and wild-type (WT) mice (n = 13), while control...
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