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Article

The role of the calcitonin receptor in protecting against induced hypercalcemia is mediated via its actions in osteoclasts to inhibit bone resorption.

Bone - 1 Feb 2011

Turner Andrew G, Tjahyono Francisca, Chiu W S Maria, Skinner Jarrod, Sawyer Rebecca, Moore Alison J, Morris Howard A, Findlay David M, Zajac Jeffrey D, Davey Rachel A

Abstract excerpt

Despite the therapeutic value of calcitonin in treating bone disease, a biological role of endogenous calcitonin is controversial. Having previously demonstrated that the CTR has a biological role in protecting against calcium stress using a global CTRKO mouse model, the purpose of this study was to determine whether the protection conferred by the CTR during induced hypercalcemia is mediated via CTR expression...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20850575
DOI: 10.1016/j.bone.2010.09.013

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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