Article
Calcitonin controls bone formation by inhibiting the release of sphingosine 1-phosphate from osteoclasts.
Nature communications - 21 Oct 2014
Keller Johannes, Catala-Lehnen Philip, Huebner Antje K, Jeschke Anke, Heckt Timo, Lueth Anja, Krause Matthias, Koehne Till, Albers Joachim, Schulze Jochen, Schilling Sarah, Haberland Michael, Denninger Hannah, Neven Mona, Hermans-Borgmeyer Irm, Streichert Thomas, Breer Stefan, Barvencik Florian, Levkau Bodo, Rathkolb Birgit, Wolf Eckhard, Calzada-Wack Julia, Neff Frauke, Gailus-Durner Valerie, Fuchs Helmut, de Angelis Martin Hrabĕ, Klutmann Susanne, Tsourdi Elena, Hofbauer Lorenz C, Kleuser Burkhard, Chun Jerold, Schinke Thorsten, Amling Michael
Abstract excerpt
The hormone calcitonin (CT) is primarily known for its pharmacologic action as an inhibitor of bone resorption, yet CT-deficient mice display increased bone formation. These findings raised the question about the underlying cellular and molecular mechanism of CT action. Here we show that either ubiquitous or osteoclast-specific inactivation of the murine CT receptor (CTR) causes increased bone formation. CT...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.