Article
Use of DNA methylation for cancer detection: promises and challenges.
The international journal of biochemistry & cell biology - 1 Jan 2009
Zhu Jingde, Yao Xuebiao
Abstract excerpt
DNA methylation is an important and reversible epigenetic modification, which regulates genomic stability and cellular plasticity. Faithful DNA methylation is essential for mammalian development and health, and perturbation of methylation dynamics contributes to the development of disease, including cancer. The discovery and validation of the biological indicators (biomarkers) for human cancers are essential...
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