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Article

Ghrelin is a novel target of Pax4 in endocrine progenitors of the pancreas and duodenum.

Developmental dynamics : an official publication of the American Association of Anatomists - 1 Jan 2008

Wang Qian, Elghazi Lynda, Martin Sophie, Martins Isabelle, Srinivasan R Satish, Geng Xin, Sleeman Mark, Collombat Patrick, Houghton Janet, Sosa-Pineda Beatriz

Abstract excerpt

Pax4-deficient mice have a severe gastrointestinal endocrine deficiency: they lack most pancreatic cells that produce insulin or somatostatin and various duodenal endocrine cell types. Remarkably, Pax4-deficient mice also have an overabundance of ghrelin-expressing cells in the pancreas and duodenum. Detailed analysis of the Pax4 nullizygous pancreas determined that the mutant islets are largely composed of a...

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Identifiers

PMID: 18058910
DOI: 10.1002/dvdy.21379

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IAPP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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