Quantitative analysis of mutation and selection pressures on base composition skews in bacterial chromosomes.

Abstract excerpt

BACKGROUND: Most bacterial chromosomes exhibit asymmetry of base composition with respect to leading vs. lagging strands (GC and AT skews). These skews reflect mainly those in protein coding sequences, which are driven by asymmetric mutation pressures during replication and transcription (notably asymmetric cytosine deamination) plus subsequent selection for preferred structures, signals, amino acid or codons....

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