Article
Similar compositional biases are caused by very different mutational effects.
Genome research - 1 Dec 2006
Rocha Eduardo P C, Touchon Marie, Feil Edward J
Abstract excerpt
Compositional replication strand bias, commonly referred to as GC skew, is present in many genomes of prokaryotes, eukaryotes, and viruses. Although cytosine deamination in ssDNA (resulting in C-->T changes on the leading strand) is often invoked as its major cause, the precise contributions of this and other substitution types are currently unknown. It is also unclear if the underlying mutational asymmetries are...
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