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Article

AMPK directly inhibits NDPK through a phosphoserine switch to maintain cellular homeostasis.

Molecular biology of the cell - 1 Jan 2012

Onyenwoke Rob U, Forsberg Lawrence J, Liu Lucy, Williams Tyisha, Alzate Oscar, Brenman Jay E

Abstract excerpt

AMP-activated protein kinase (AMPK) is a key energy sensor that regulates metabolism to maintain cellular energy balance. AMPK activation has also been proposed to mimic benefits of caloric restriction and exercise. Therefore, identifying downstream AMPK targets could elucidate new mechanisms for maintaining cellular energy homeostasis. We identified the phosphotransferase nucleoside diphosphate kinase (NDPK),...

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Identifiers

PMID: 22114351
DOI: 10.1091/mbc.E11-08-0699
PMCID: PMC3258181

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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