Article
Enhanced Vulnerability of LKB1-Deficient NSCLC to Disruption of ATP Pools and Redox Homeostasis by 8-Cl-Ado.
Molecular cancer research : MCR - 1 Feb 2022
Galan-Cobo Ana, Stellrecht Christine M, Yilmaz Emrullah, Yang Chao, Qian Yu, Qu Xiao, Akhter Ishita, Ayres Mary L, Fan Youhong, Tong Pan, Diao Lixia, Ding Jie, Giri Uma, Gudikote Jayanthi, Nilsson Monique, Wierda William G, Wang Jing, Skoulidis Ferdinandos, Minna John D, Gandhi Varsha, Heymach John V
Abstract excerpt
Loss-of-function somatic mutations of STK11, a tumor suppressor gene encoding LKB1 that contributes to the altered metabolic phenotype of cancer cells, is the second most common event in lung adenocarcinomas and often co-occurs with activating KRAS mutations. Tumor cells lacking LKB1 display an aggressive phenotype, with uncontrolled cell growth and higher energetic and redox stress due to its failure to balance...
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