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Phosphoglycerate kinase 1 as a therapeutic target in neurological disease

14 Apr 2025

Abstract excerpt

Phosphoglycerate kinase 1 (PGK1) is a highly conserved enzyme that catalyzes the initial ATP-producing step in glycolysis. Improving cellular energy production by increasing PGK1 activity may be beneficial in multiple neurological conditions where cell metabolism is dysregulated, including Parkinson's disease (PD) and motor neuron disease (MND). This review examines recent evidence that suggests increasing PGK1...

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PMID: 40234116
DOI: 10.1016/j.molmed.2025.03.008

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