Article

The Class I E3 Ubiquitin Ligase TRIM67 Modulates Brain Development and Behavior

2017-12-30

Abstract excerpt

<h4>ABSTRACT</h4> Specific class I members of the TRIM family of E3 ubiquitin ligases have been implicated in neuronal development from invertebrates to mammals. The single invertebrate class I TRIM and mammalian TRIM9 regulate axon branching and guidance in response to the axon guidance cue netrin-1, whereas mammalian TRIM46 establishes the axon initial segment. In humans, mutations in TRIM1 and TRIM18 are impli...

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Literature Corpus work: ace4df4d-5af5-55e0-b744-dae885fdafbf
DOI: 10.1101/241331

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