Article
MOZ regulates the Tbx1 locus, and Moz mutation partially phenocopies DiGeorge syndrome.
Developmental cell - 11 Sept 2012
Voss Anne K, Vanyai Hannah K, Collin Caitlin, Dixon Mathew P, McLennan Tamara J, Sheikh Bilal N, Scambler Peter, Thomas Tim
Abstract excerpt
DiGeorge syndrome, caused by a 22q11 microdeletion or mutation of the TBX1 gene, varies in severity greatly, even among monozygotic twins. Epigenetic phenomena have been invoked to explain phenotypic differences in individuals of identical genetic composition, although specific chromatin modifications relevant to DiGeorge syndrome are elusive. Here we show that lack of the histone acetyltransferase MOZ...
Topics
- Animals
- DiGeorge Syndrome
- Histone Acetyltransferases
- Mice
- Mice, Inbred Strains
- Mice, Transgenic
- Mutation
- Phenotype
- T-Box Domain Proteins