Article
Depletion of the p43 mitochondrial T3 receptor in mice affects skeletal muscle development and activity.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Feb 2012
Pessemesse Laurence, Schlernitzauer Audrey, Sar Chamroeun, Levin Jonathan, Grandemange Stéphanie, Seyer Pascal, Favier François B, Kaminski Sandra, Cabello Gérard, Wrutniak-Cabello Chantal, Casas François
Abstract excerpt
In vertebrates, skeletal muscle myofibers display different contractile and metabolic properties associated with different mitochondrial content and activity. We have previously identified a mitochondrial triiodothyronine receptor (p43) regulating mitochondrial transcription and mitochondrial biogenesis. When overexpressed in skeletal muscle, it increases mitochondrial DNA content, stimulates mitochondrial...
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