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Regulation of skeletal muscle mitochondrial function by nuclear receptors: implications for health and disease

14 Jul 2015

Abstract excerpt

Skeletal muscle metabolism is highly dependent on mitochondrial function, with impaired mitochondrial biogenesis associated with the development of metabolic diseases such as insulin resistance and type 2 diabetes. Mitochondria display substantial plasticity in skeletal muscle, and are highly sensitive to levels of physical activity. It is thought that physical activity promotes mitochondrial biogenesis in...

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PMID: 26186742
DOI: 10.1042/cs20150246

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