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Article

PmrB mutations promote polymyxin resistance of Pseudomonas aeruginosa isolated from colistin-treated cystic fibrosis patients.

Antimicrobial agents and chemotherapy - 1 Feb 2012

Moskowitz Samuel M, Brannon Mark K, Dasgupta Nandini, Pier Miyuki, Sgambati Nicole, Miller Amanda K, Selgrade Sara E, Miller Samuel I, Denton Miles, Conway Steven P, Johansen Helle K, Høiby Niels

Abstract excerpt

Pseudomonas aeruginosa can develop resistance to polymyxin and other cationic antimicrobial peptides. Previous work has shown that mutations in the PmrAB and PhoPQ regulatory systems can confer low to moderate levels of colistin (polymyxin E) resistance in laboratory strains and clinical isolates of this organism (MICs of 8 to 64 mg/liter). To explore the role of PmrAB in high-level clinical polymyxin resistance,...

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Identifiers

PMID: 22106224
DOI: 10.1128/AAC.05829-11
PMCID: PMC3264203

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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PmrB mutations promote polymyxin resistance of Pseudomonas aeruginosa isolated from colistin-treated cystic fibrosis patients.PMID 22106224Read ↗

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