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Article

Development of colistin resistance in pmrA-, phoP-, parR- and cprR-inactivated mutants of Pseudomonas aeruginosa.

The Journal of antimicrobial chemotherapy - 1 Nov 2014

Lee Ji-Young, Chung Eun Seon, Na In Young, Kim Hyunkeun, Shin Dongwoo, Ko Kwan Soo

Abstract excerpt

OBJECTIVES: Colistin susceptibility in Pseudomonas aeruginosa is associated with a lipopolysaccharide (LPS) structure that is controlled by the modulation of several two-component regulatory systems. In this study, we attempted to elucidate the role of these two-component systems in the development of colistin resistance in P. aeruginosa. METHODS: pmrA-, phoP-, parR- or cprR-inactivated mutants were constructed...

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Identifiers

PMID: 24994873
DOI: 10.1093/jac/dku238

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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