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Article

Polymyxin resistance of Pseudomonas aeruginosa phoQ mutants is dependent on additional two-component regulatory systems.

Antimicrobial agents and chemotherapy - 1 May 2013

Gutu Alina D, Sgambati Nicole, Strasbourger Pnina, Brannon Mark K, Jacobs Michael A, Haugen Eric, Kaul Rajinder K, Johansen Helle Krogh, Høiby Niels, Moskowitz Samuel M

Abstract excerpt

Pseudomonas aeruginosa can develop resistance to polymyxin as a consequence of mutations in the PhoPQ regulatory system, mediated by covalent lipid A modification. Transposon mutagenesis of a polymyxin-resistant phoQ mutant defined 41 novel loci required for resistance, including two regulatory systems, ColRS and CprRS. Deletion of the colRS genes, individually or in tandem, abrogated the polymyxin resistance of...

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Identifiers

PMID: 23459479
DOI: 10.1128/AAC.02353-12
PMCID: PMC3632916

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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