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Article

Resistance to colistin in Acinetobacter baumannii associated with mutations in the PmrAB two-component system.

Antimicrobial agents and chemotherapy - 1 Sept 2009

Adams Mark D, Nickel Gabrielle C, Bajaksouzian Saralee, Lavender Heather, Murthy A Rekha, Jacobs Michael R, Bonomo Robert A

Abstract excerpt

The mechanism of colistin resistance (Col(r)) in Acinetobacter baumannii was studied by selecting in vitro Col(r) derivatives of the multidrug-resistant A. baumannii isolate AB0057 and the drug-susceptible strain ATCC 17978, using escalating concentrations of colistin in liquid culture. DNA sequencing identified mutations in genes encoding the two-component system proteins PmrA and/or PmrB in each strain and in a...

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Identifiers

PMID: 19528270
DOI: 10.1128/AAC.00284-09
PMCID: PMC2737849

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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