Article
Pseudomonas aeruginosa high-level resistance to polymyxins and other antimicrobial peptides requires cprA, a gene that is disrupted in the PAO1 strain.
Antimicrobial agents and chemotherapy - 1 Sept 2015
Gutu Alina D, Rodgers Nicole S, Park Jihye, Moskowitz Samuel M
Abstract excerpt
The arn locus, found in many Gram-negative bacterial pathogens, mediates resistance to polymyxins and other cationic antimicrobial peptides through 4-amino-l-arabinose modification of the lipid A moiety of lipopolysaccharide. In Pseudomonas aeruginosa, several two-component regulatory systems (TCSs) control the arn locus, which is necessary but not sufficient for these resistance phenotypes. A previous transposon...
Topics
- Anti-Bacterial Agents
- Bacterial Proteins
- Drug Resistance, Bacterial
- Mutation
- Polymyxins
- Pseudomonas aeruginosa