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Article

Mutations profile of polycythemia vera and essential thrombocythemia among Japanese children.

Pediatric blood & cancer - 1 Sept 2012

Ismael Olfat, Shimada Akira, Hama Asahito, Sakaguchi Hiroshi, Doisaki Sayoko, Muramatsu Hideki, Yoshida Nao, Ito Masafumi, Takahashi Yoshiyuki, Akita Naohiro, Sunami Shosuke, Ohtsuka Yoshitoshi, Asada Youji, Fujisaki Hiroyuki, Kojima Seiji

Abstract excerpt

BACKGROUND: Acquired somatic mutations of JAK2 have been reported to play a pivotal role in the pathogenesis of BCR-ABL1-negative myeloproliferative neoplasm (MPN). However, the molecular characteristics of childhood MPN remain to be elucidated. PATIENT AND METHODS: We investigated a group of pediatric patients diagnosed either with essential thrombocythemia (ET; N = 9) or polycythemia vera (PV; N = 4) according...

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Source

Identifiers

PMID: 22106054
DOI: 10.1002/pbc.23409

Genes

JAK2
ASXL1
CBL
IDH1
IDH2
MPL
TET2
ABL1
BCR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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