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Features and Allele Frequency of JAK2 Exon 12-Mutated Polycythemia Vera in Comparison with JAK2V617F-Mutated Disease.

Archives of medical research - 1 Feb 2025

Chuang Chin-Hsuan, Kuo Ming-Chung, Wu Jin-Hou, Lin Tung-Liang, Wang Po-Nan, Chang Yueh-Shih, Lin Tung-Hui, Huang Ting-Yu, Hung Yu-Shin, Kao Hsiao-Wen, Ou Che-Wei, Chang Hung, Shih Lee-Yung

Abstract excerpt

BACKGROUND AND AIM: JAK2 exon 12 mutation status and the clinical characteristics of patients with polycythemia vera (PV) in Asia remain to be defined. METHOD: We analyzed the clinical, molecular, and genetic features and outcomes of patients with PV harboring exon 12 mutation and compared them with the JAK2V617F-mutated patients in Taiwan. JAK2V617F with allele burden was measured by pyrosequencing and/or...

Topics

Humans
Janus Kinase 2
Polycythemia Vera
Male
Female
Middle Aged
Exons
Aged
Gene Frequency
Mutation
Taiwan

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Adult

Aged, 80 and over

Alleles

Source

Identifiers

PMID: 39461040
DOI: 10.1016/j.arcmed.2024.103109

Genes

JAK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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