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Features and Allele Frequency of JAK2 Exon 12-Mutated Polycythemia Vera in Comparison with JAK2V617F-Mutated Disease.

Archives of medical research - 1 Feb 2025

Chuang Chin-Hsuan, Kuo Ming-Chung, Wu Jin-Hou, Lin Tung-Liang, Wang Po-Nan, Chang Yueh-Shih, Lin Tung-Hui, Huang Ting-Yu, Hung Yu-Shin, Kao Hsiao-Wen, Ou Che-Wei, Chang Hung, Shih Lee-Yung

Abstract excerpt

BACKGROUND AND AIM: JAK2 exon 12 mutation status and the clinical characteristics of patients with polycythemia vera (PV) in Asia remain to be defined. METHOD: We analyzed the clinical, molecular, and genetic features and outcomes of patients with PV harboring exon 12 mutation and compared them with the JAK2V617F-mutated patients in Taiwan. JAK2V617F with allele burden was measured by pyrosequencing and/or...

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PMID: 39461040
DOI: 10.1016/j.arcmed.2024.103109

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JAK2

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