Article
TET2 mutations in Ph-negative myeloproliferative neoplasms: identification of three novel mutations and relationship with clinical and laboratory findings.
BioMed research international - 1 Jan 2013
Patriarca Andrea, Colaizzo Donatella, Tiscia Gianluca, Spadano Raffaele, Di Zacomo Silvia, Spadano Antonio, Villanova Ida, Margaglione Maurizio, Grandone Elvira, Dragani Alfredo
Abstract excerpt
High-throughput DNA sequence analysis was used to screen for TET2 mutations in peripheral blood derived DNA from 97 patients with BCR-ABL-negative myeloproliferative neoplasms (MPNs). Overall six mutations in the coding region of the gene were identified in 7 patients with an overall mutational frequency of 7.2%. In polycythemia vera patients (n = 25) 2 mutations were identified (8%), and in those with essential...
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