Article
TET2 mutations and their clinical correlates in polycythemia vera, essential thrombocythemia and myelofibrosis.
Leukemia - 1 May 2009
Tefferi A, Pardanani A, Lim K-H, Abdel-Wahab O, Lasho T L, Patel J, Gangat N, Finke C M, Schwager S, Mullally A, Li C-Y, Hanson C A, Mesa R, Bernard O, Delhommeau F, Vainchenker W, Gilliland D G, Levine R L
Abstract excerpt
High-throughput DNA sequence analysis was used to screen for TET2 mutations in bone marrow-derived DNA from 239 patients with BCR-ABL-negative myeloproliferative neoplasms (MPNs). Thirty-two mutations (19 frameshift, 10 nonsense, 3 missense; mostly involving exons 4 and 12) were identified for an overall mutational frequency of approximately 13%. Specific diagnoses included polycythemia vera (PV; n=89), essential...
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