Article
TET2, ASXL1, IDH1, and IDH2 Single Nucleotide Polymorphisms in Turkish Patients with Chronic Myeloproliferative Neoplasms.
Turkish journal of haematology : official journal of Turkish Society of Haematology - 5 Jun 2017
Soyer Nur, Tezcanlı Kaymaz Burçin, Cömert Özkan Melda, Aktan Çağdaş, Küçükaslan Ali Şahin, Şahin Fahri, Kosova Buket, Saydam Güray
Abstract excerpt
We aimed to determine the genotype distribution, allele frequency, and prognostic impact of IDH1/2, TET2, and ASXL1 single nucleotide polymorphisms (SNPs) in myeloproliferative neoplasms (MPNs). TET2 (rs763480), ASXL1 (rs2208131), and IDH1 (rs11554137) variant homozygous genotype frequencies were found at rates of 1.5%, 9.2%, and 2.3%, respectively. No IDH2 SNP was identified. IDH1 and TET2 frequencies were 5% in...
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