Article
Polycythemia vera and essential thrombocythemia: new developments in biology with therapeutic implications.
Current opinion in hematology - 1 Mar 2013
Soriano Gabriela, Heaney Mark
Abstract excerpt
PURPOSE OF REVIEW: This review summarizes current understanding of the molecular genetics of polycythemia vera and essential thrombocythemia, with an emphasis on JAK2V617F pathophysiology and effect on disease phenotype. RECENT FINDINGS: JAK2V617F exerts its effects on cell growth via janus kinase-signal transducer and activator of transcription (JAK-STAT) signalling and interactions with other molecules that...
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