Polycythemia vera and essential thrombocythemia:  new developments in biology with therapeutic implications.

doi:10.1097/MOH.0b013e32835d82fe

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Polycythemia vera and essential thrombocythemia: new developments in biology with therapeutic implications.

Current opinion in hematology - 1 Mar 2013

Soriano Gabriela, Heaney Mark

Abstract excerpt

PURPOSE OF REVIEW: This review summarizes current understanding of the molecular genetics of polycythemia vera and essential thrombocythemia, with an emphasis on JAK2V617F pathophysiology and effect on disease phenotype. RECENT FINDINGS: JAK2V617F exerts its effects on cell growth via janus kinase-signal transducer and activator of transcription (JAK-STAT) signalling and interactions with other molecules that...

Topics

DNA Methyltransferase 3A
Disease Progression
Humans
Janus Kinase 2
Mutation
Phenotype
Polycythemia Vera
Thrombocythemia, Essential

Source

Open in PubMed

Identifiers

PMID: 23298878
DOI: 10.1097/MOH.0b013e32835d82fe

Genes

JAK2
ASXL1
CBL
IDH2
RUNX1
SRSF2
TET2

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.