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A vaccine targeting lung resident-memory CD4+ T cell phenotype protects against Mycobacterium tuberculosis in mice

22 Jul 2025

Abstract excerpt

Lung-resident memory T (T RM ) cells respond rapidly and effectively to respiratory pathogen invasion, suppressing pathogen proliferation. Previously, we identified a defined TLR3 agonist called Nexavant (NVT) and developed a vaccine platform that utilizes it to induce lung T RM . In this study, we aimed to determine whether the protective effect of T RM cells is observed in tuberculosis (TB), a chronic bacterial...

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PMID: 40695843
DOI: 10.1038/s41541-025-01225-7

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