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Article

The MOV10 helicase restricts hepatitis B virus replication by inhibiting viral reverse transcription.

The Journal of biological chemistry - 20 Dec 2019

Liu Tingting, Sun Qingsong, Liu Yong, Cen Shan, Zhang Quan

Abstract excerpt

Interferons inhibit viruses by inducing antiviral protein expression. One of the interferon-induced antiviral proteins, human Moloney leukemia virus 10 (MOV10), a superfamily 1 RNA helicase, has been shown to inhibit retroviruses and several RNA viruses. However, it remains undetermined whether MOV10 also inhibits DNA viruses, including hepatitis B virus (HBV). Here, we report that MOV10 dramatically reduces the...

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Share to DNA Helicases
Share to Gene Expression Regulation, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hep G2 Cells

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Source

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Identifiers

PMID: 31722967
DOI: 10.1074/jbc.RA119.009435
PMCID: PMC6926444

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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