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MOV10 Helicase Interacts with Coronavirus Nucleocapsid Protein and Has Antiviral Activity

14 Sept 2021

Abstract excerpt

Coronaviruses (CoVs) are emerging pathogens causing life-threatening diseases in humans. Knowledge of virus-host interactions and viral subversion mechanisms of host pathways is required for the development of effective countermeasures against CoVs. The interaction between cellular RNA helicase MOV10 and nucleocapsid (N) protein from several human CoVs is shown. Using MERS-CoV as a model, we demonstrate that...

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PMID: 34517762
DOI: 10.1128/mbio.01316-21

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